Effect of intravenous ascorbic acid in hemodialysis patients with anemia and hyperferritinemia.

Hemodialysis (HD) patients with functional iron deficiency (FID) often develop resistance to recombinant human erythropoietin (Epo). The contributory role of chronic inflammation and oxidative stress in its pathogenesis is poorly understood. We assessed the effect of vitamin C, an antioxidant, on Epo-hyporesponsive anemia in hemodialysis patients with un-explained hyperferritinemia levels. Thirty-one of 132 with Hb 15 patients received standard care and 300 mg of intravenous vitamin C with each dialysis session (group 1) and 15 patients received standard care (group 2). After 3 months, Hb and transferrin saturation levels significantly increased in group 1 but not in group 2 (p < 0.05%). Hemoglobin content in reticulocyte and serum ferritin decreased significantly in group 1 but not in control group. In conclusion, hemodialysis patients with refractory anemia and adequate iron stores, vitamin C improved responsiveness to Epo by augmenting iron mobilization and possibly via antioxidant effect.
AuthorsKeyhanian Shahrbanoo, Omolbanin Taziki
JournalSaudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (Saudi J Kidney Dis Transpl) Vol. 19 Issue 6 Pg. 933-6 (Nov 2008) ISSN: 1319-2442 [Print] Saudi Arabia
PMID18974579 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Antioxidants
  • Recombinant Proteins
  • Erythropoietin
  • Ferritins
  • Ascorbic Acid
  • Anemia, Refractory (drug therapy, etiology)
  • Antioxidants (administration & dosage)
  • Ascorbic Acid (administration & dosage)
  • Erythropoietin (therapeutic use)
  • Female
  • Ferritins (blood)
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Recombinant Proteins
  • Renal Dialysis
  • Reticulocytes (chemistry)

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