Antimicrobial activity of the ornamental species Salvia corrugata, a potential new crop for extractive purposes.

Abstract

As a part of our search for biologically active compounds from cultivated Salvia spp. we investigated Salvia corrugata Vahl. The activity of two isolated icetaxane diterpene quinones, fruticuline A and demethylfruticuline A, was assessed against 46 bacterial pathogens, mostly resistant to several primary antibiotics. The MIC for all the inhibited Gram-positive pathogens tested showed a very narrow distribution and ranged from 32 to 64 mg/L, regardless of their resistance patterns to other antibiotics. Demethylfruticuline A was shown to be highly bactericidal (>3 log(10) CFU decrease within 24 h) against Staphylococcus aureus and S. epidermidis and bacteriostatic against Enterococcus faecalis and E. faecium. Fruticuline A manifested bacteriostatic activity against all tested strains. S. corrugata can be viewed as an interesting source for these diterpenes, which, if well tolerated in vivo, may represent new medical agents useful for the treatment of serious infections caused by resistant Gram-positive pathogens.

• Authors: Angela Bisio, Giovanni Romussi, Eleonora Russo, Sergio Cafaggi, Anna Maria Schito, Barbara Repetto, Nunziatina De Tommasi
• Journal: Journal of agricultural and food chemistry (J Agric Food Chem) Vol. 56 Issue 22 Pg. 10468-72 (Nov 26 2008) ISSN: 1520-5118 [Electronic] United States
• PMID: 18973336 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Diterpenes
• Plant Extracts
• demethylfruticuline A
• fruticuline A

Topics

• Anti-Bacterial Agents (pharmacology)
• Diterpenes (pharmacology)
• Drug Resistance, Microbial
• Gram-Positive Bacteria (drug effects)
• Microbial Sensitivity Tests
• Plant Extracts (chemistry)
• Plant Leaves (chemistry)
• Salvia (chemistry)