HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Renal handling of matrix Gla-protein in humans with moderate to severe hypertension.

Abstract
Vascular calcifications are common among patients with hypertension. The vitamin K-dependent protein matrix Gla-protein plays an important role in preventing arterial calcification. Since a decrease in renal clearance is a prevalent clinical problem in patients with hypertension, we aimed to study the renal clearance of matrix Gla-protein from the circulation in these patients having a wide range of creatinine clearances. Ninety moderate to severe hypertensive patients who were scheduled for renal angiography were enrolled in the study. In these patients, renal arterial and renal venous blood was sampled prior to the administration of contrast material in order to determine the total renal and single kidney clearance of matrix Gla-protein. The average renal fractional extraction of matrix Gla-protein was 12.8%. There was no significant correlation between creatinine clearance (range 26-154) and renal fractional extraction of matrix Gla-protein in this population. The extraction of matrix Gla-protein was not influenced by the presence of a renal artery stenosis. In conclusion, we demonstrate that the kidney is able to extract matrix Gla-protein from the plasma at a constant level of 12.8%, independent of renal function in hypertensive subjects.
AuthorsRoger J M W Rennenberg, Leon J Schurgers, Cees Vermeer, Jan B J Scholte, Alphons J H M Houben, Peter W de Leeuw, Abraham A Kroon
JournalHypertension research : official journal of the Japanese Society of Hypertension (Hypertens Res) Vol. 31 Issue 9 Pg. 1745-51 (Sep 2008) ISSN: 0916-9636 [Print] England
PMID18971553 (Publication Type: Journal Article)
Chemical References
  • Calcium-Binding Proteins
  • Extracellular Matrix Proteins
  • matrix Gla protein
  • Creatinine
Topics
  • Adult
  • Calcinosis (metabolism)
  • Calcium-Binding Proteins (blood)
  • Creatinine (metabolism)
  • Extracellular Matrix Proteins (blood)
  • Female
  • Humans
  • Hypertension, Renal (metabolism)
  • Kidney (metabolism)
  • Male
  • Middle Aged
  • Renal Artery
  • Renal Artery Obstruction (metabolism)
  • Renal Circulation
  • Renal Veins
  • Severity of Illness Index

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: