HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Improvement of hyperglycemia and hyperlipemia in streptozotocin-diabetic rats by a methanolic extract of Prunus davidiana stems and its main component, prunin.

Abstract
Blood glucose and total lipid levels in rats with streptozotocin-induced diabetes were determined after intraperitoneal administration of a methanolic extract of Prunus davidiana Fr. stems and its main component, prunin (= naringenin 7-O-beta-D-glucoside). From the data obtained it was concluded that intraperitoneal administration of the methanolic extract and prunin produced a significant hypoglycemic effect. Total blood lipids were also decreased by these substances. Thus, it is suggested that this methanolic extract contains one or more hypoglycemic principles including the main flavanone glycoside, prunin, which can significantly reduce the levels of blood glucose and total lipids in streptozotocin-diabetic rats.
AuthorsJ S Choi, T Yokozawa, H Oura
JournalPlanta medica (Planta Med) Vol. 57 Issue 3 Pg. 208-11 (Jun 1991) ISSN: 0032-0943 [Print] GERMANY
PMID1896517 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Flavonoids
  • Globulins
  • Plant Extracts
  • Plant Proteins
  • prunin protein, Prunus
Topics
  • Animals
  • Diabetes Mellitus, Experimental (complications, drug therapy)
  • Flavonoids (therapeutic use)
  • Globulins
  • Hyperglycemia (drug therapy, etiology)
  • Hyperlipidemias (drug therapy, etiology)
  • Male
  • Plant Extracts (therapeutic use)
  • Plant Proteins
  • Rats
  • Rats, Inbred Strains

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: