Abstract | BACKGROUND: The purpose of this trial was to evaluate the efficacy of a low-animal- protein diet (LAPD) or a high-fiber diet (HFD) for the prevention of calcium nephrolithiasis recurrence. METHODS: We conducted a 4-year randomized trial comparing the effect of 2 diets in 175 idiopathic calcium stone formers. Fifty-five were assigned to a LAPD (<13% of total energy derived from protein), 60 were assigned to a HFD (>25 g/day fiber) and 60 were placed on a normal diet (control group). The primary outcome measure was the time to the first recurrence of calcium nephrolithiasis. Daily urine compositions were analyzed at baseline, at month 4 (M4), M12, M24, M36 and M48. RESULTS: Seventy-three patients completed the trial (23 in the LAPD group, 27 in the HFD group and 23 in the control group). Recurrence was 48% (11/23) in the LAPD group, 63% (17/27) in the HFD group and 48% (11/23) in the control group (p = not significant). During follow-up, urinary calcium levels and other urine parameters did not change significantly in the 3 groups, except for a significant decrease in 24-hour urinary sulfate in the LAPD group. CONCLUSIONS: In idiopathic calcium stone formers, neither a LAPD nor a HFD appeared to provide protection against recurrence.
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Authors | Bertrand Dussol, Cecilia Iovanna, Michel Rotily, Sophie Morange, Françoise Leonetti, Patricia Dupuy, Alain Vazi, Adriana Saveanu, Anderson Loundou, Yvon Berland |
Journal | Nephron. Clinical practice
(Nephron Clin Pract)
Vol. 110
Issue 3
Pg. c185-94
( 2008)
ISSN: 1660-2110 [Electronic] Switzerland |
PMID | 18957869
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright 2008 S. Karger AG, Basel. |
Chemical References |
- Dietary Fiber
- Dietary Proteins
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Topics |
- Adult
- Dietary Fiber
(therapeutic use)
- Dietary Proteins
(therapeutic use)
- Female
- Humans
- Male
- Middle Aged
- Nephrocalcinosis
(diagnosis, diet therapy, prevention & control)
- Nephrolithiasis
(diagnosis, diet therapy, prevention & control)
- Secondary Prevention
- Treatment Outcome
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