Rapid encephalopathy associated with anti-D immune globulin treatment for idiopathic thrombocytopenic purpura.

Abstract	Rho (D) immune globulin intravenous (IV RhIG, WinRho SDF) has been shown to be a safe treatment for idiopathic thrombocytopenic purpura. Common side effects of IV RhIG include mild hemolysis, febrile reaction and headache. Significant hemolysis with renal impairment is infrequently noted. A single case of irreversible encephalopathy following IV RhIG has been reported. We report a second case of encephalopathy following an infusion of IV RhIG for treatment of idiopathic thrombocytopenic purpura.
Authors	Sunitha Golla, Clare Horkan, Grigore Dogaru, Thomas E Teske, Kenneth Christopher
Journal	Acta haematologica (Acta Haematol) Vol. 120 Issue 2 Pg. 100-3 ( 2008) ISSN: 1421-9662 [Electronic] Switzerland
PMID	18957844 (Publication Type: Case Reports, Journal Article)
Chemical References	Rho(D) Immune Globulin
Topics	Aged, 80 and over Cerebral Hemorrhage Fatal Outcome Female Humans Neurotoxicity Syndromes (diagnosis, etiology) Purpura, Thrombocytopenic, Idiopathic (complications, drug therapy) Rho(D) Immune Globulin (adverse effects)

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