Abstract |
Mahwangyounpae-tang (MT), consisting of 22 types of herbal extracts has been used for thousands of years in Korean traditional medicine for the oral treatment of respiratory diseases including asthma. As part of a safety evaluation of MT extracts for use in asthma, the potential genotoxicity of an aqueous MT extract was evaluated using the standard battery of tests (bacterial reverse mutation assay; chromosomal aberrations assay; mouse micronucleus assay) recommended by Korea Food and Drug Administration (KFDA). The MT extract was determined not to be genotoxic under the conditions of the reverse mutation assay, chromosomal aberrations assay and mouse micronucleus assay. Use of MT is presently expected to be safe, as anticipated intake is small compared to the doses administered in the genotoxicity assays and may, after further toxicity research, prove to be a useful anti- asthma agent.
|
Authors | Jeng-Yim Seo, Mee-Yeon Park, Tae-Young Jung, Hae-Yun Choi, Jong-Dae Kim, Hyeung-Sik Lee, Sae-Kwang Ku |
Journal | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
(Food Chem Toxicol)
Vol. 46
Issue 12
Pg. 3827-31
(Dec 2008)
ISSN: 0278-6915 [Print] England |
PMID | 18957314
(Publication Type: Journal Article)
|
Chemical References |
- Anti-Asthmatic Agents
- Mutagens
- Plant Extracts
- mahwangyounpae-tang
- Water
|
Topics |
- Animals
- Anti-Asthmatic Agents
(toxicity)
- Chromosome Aberrations
(drug effects)
- Medicine, Korean Traditional
- Mice
- Mice, Inbred ICR
- Micronucleus Tests
- Mutagenicity Tests
- Mutagens
(toxicity)
- Plant Extracts
(toxicity)
- Rats
- Water
|