Double-blind trial of oral carbuterol in bronchial asthma.

Abstract

A double-blind comparison of 2 and 3 mg oral doses of carbuterol, a beta sympathomimetic drug with preferential selectivity for bronchial smooth muscle, was made with 25 and 35 mg doses of ephedrine sulfate over a six-month period in 26 patients with bronchial asthma. Spirometry was done before and three hours after administration of 3 mg of carbuterol or 35 mg of ephedrine sulfate at intervals of two weeks and one, four and six months. The data suggest a cumulative improvement in pulmonary function status with continued oral carbuterol use over the six-month period. However, the clinical effectiveness of the drug on pulmonary function was not clearly distinguishable from that of ephedrine in the present study.

• Authors: J Miller, D Wallace, M H Grieco, R Frenkel, K Larsen
• Journal: Annals of allergy (Ann Allergy) Vol. 39 Issue 1 Pg. 12-7 (Jul 1977) ISSN: 0003-4738 [Print] United States
• PMID: 18957 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Adrenergic beta-Agonists
• Ethanolamines
• Phenylurea Compounds
• Ephedrine

Topics

• Adrenergic beta-Agonists (adverse effects, pharmacology, therapeutic use)
• Adult
• Asthma (drug therapy, physiopathology)
• Clinical Trials as Topic
• Double-Blind Method
• Drug Evaluation
• Ephedrine (adverse effects, pharmacology, therapeutic use)
• Ethanolamines (therapeutic use)
• Hemodynamics (drug effects)
• Humans
• Middle Aged
• Phenylurea Compounds (adverse effects, pharmacology, therapeutic use)
• Respiratory Function Tests
• Tremor (chemically induced)