Continuous regional arterial infusion therapy for acute necrotizing pancreatitis due to Mycoplasma pneumoniae infection in a child.

Abstract

A case of acute necrotizing pancreatitis due to Mycoplasma pneumoniae infection was treated in an 8-year-old girl. She experienced acute pancreatitis during treatment for M. pneumoniae. Contrast-enhanced computed tomographic scan revealed necrotizing pancreatitis. The computed tomographic severity index was 8 points (grade E). A protease inhibitor, ulinastatin, was provided via intravenous infusion but was ineffective. Continuous regional arterial infusion therapy was provided with gabexate mesilate (FOY-007, a protease inhibitor) and meropenem trihydrate, and the pancreatitis improved. This case suggests that infusion therapy is safe and useful in treating necrotizing pancreatitis in children.

• Authors: Motoo Nakagawa, Hiroyuki Ogino, Masashi Shimohira, Masaki Hara, Yuta Shibamoto
• Journal: Cardiovascular and interventional radiology (Cardiovasc Intervent Radiol) Vol. 32 Issue 3 Pg. 581-4 (May 2009) ISSN: 1432-086X [Electronic] United States
• PMID: 18956223 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Contrast Media
• Serine Proteinase Inhibitors
• Thienamycins
• Gabexate
• Meropenem

Topics

• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• Child
• Contrast Media
• Drug Therapy, Combination
• Female
• Gabexate (administration & dosage, therapeutic use)
• Humans
• Infusions, Intra-Arterial
• Meropenem
• Mycoplasma pneumoniae (isolation & purification)
• Pancreatitis, Acute Necrotizing (drug therapy, microbiology)
• Pneumonia, Mycoplasma (complications)
• Serine Proteinase Inhibitors (administration & dosage, therapeutic use)
• Thienamycins (administration & dosage, therapeutic use)
• Tomography, X-Ray Computed