Abstract | BACKGROUND: Safe and effective treatment for chronic inflammatory and neuropathic pain remains a key unmet medical need for many patients. The recent discovery and description of the transient receptor potential family of receptors including TRPV1 and TRPA1 has provided a number of potential new therapeutic targets for treating chronic pain. Recent reports have suggested that TRPA1 may play an important role in acute formalin and CFA induced pain. The current study was designed to further explore the therapeutic potential of pharmacological TRPA1 antagonism to treat inflammatory and neuropathic pain. RESULTS: CONCLUSION: Using oral administration of the selective TRPA1 antagonist HC-030031, our results demonstrated that TRPA1 plays an important role in the mechanisms responsible for mechanical hypersensitivity observed in inflammatory and neuropathic pain models. These findings suggested that TRPA1 antagonism may be a suitable new approach for the development of a potent and selective therapeutic agent to treat both inflammatory and neuropathic pain.
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Authors | Samer R Eid, Eric D Crown, Eric L Moore, Hongyu A Liang, Kar-Chan Choong, Shelley Dima, Darrell A Henze, Stefanie A Kane, Mark O Urban |
Journal | Molecular pain
(Mol Pain)
Vol. 4
Pg. 48
(Oct 27 2008)
ISSN: 1744-8069 [Electronic] United States |
PMID | 18954467
(Publication Type: Journal Article)
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Chemical References |
- 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide
- Acetanilides
- Analgesics
- Ankyrins
- Calcium Channels
- Nerve Tissue Proteins
- Purines
- TRPA1 Cation Channel
- TRPA1 protein, human
- TRPC Cation Channels
- Transient Receptor Potential Channels
- Trpa1 protein, rat
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Topics |
- Acetanilides
(pharmacology)
- Analgesics
(pharmacology)
- Animals
- Ankyrins
- Calcium Channels
(physiology)
- Cell Line
- Disease Models, Animal
- Humans
- Inflammation
- Male
- Nerve Tissue Proteins
(antagonists & inhibitors, physiology)
- Neuralgia
(drug therapy, etiology, pathology)
- Pain
(drug therapy, etiology, pathology)
- Purines
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- TRPA1 Cation Channel
- TRPC Cation Channels
- Transient Receptor Potential Channels
(antagonists & inhibitors, physiology)
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