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Serum 5-S-cysteinyldopa levels in patients with psoriasis undergoing narrowband ultraviolet B phototherapy.

AbstractBACKGROUND:
Ultraviolet (UV) B radiation from sunlight can result in tanning or burning of the skin. Narrowband UVB (NB-UVB), a relatively new light source that is not yet widely available, is effective for treating generalized psoriasis without the use of psoralens.
AIMS:
The melanin-related metabolite 5-S-cysteinyldopa (5-S-CD), which reflects pheomelanin production, has been used as a biological marker of melanoma progression, but there are no studies available on therapeutic UVB effects on serum 5-S-CD of human subjects. In the present study, we measured the time course of changes in serum levels of 5-S-CD in patients with psoriasis undergoing NB-UVB phototherapy.
METHODS:
In total, 11 Japanese patients with generalized psoriasis vulgaris received NB-UVB treatment five times per week, at an initial dose of 0.1 J/cm(2). The dose was increased by 10-20% per treatment for > 20 treatments. Serum samples were taken before and 3, 7, 10, 14 and 28 days after phototherapy.
RESULTS:
After 4 weeks of NB-UVB treatment, 9 of 11 patients were in remission, confirming the effectiveness of NB-UVB for treating Japanese patients with psoriasis. Two patients withdrew before day 28 because of other complications. Mean level of 5-S-CD in serum was significantly increased on day 7, 10 14 and 28 compared with the level before phototherapy and it peaked on day 10.
CONCLUSIONS:
Serum 5-S-CD levels were significantly increased by therapeutic UVB exposure. Sustained levels of 5-S-CD in serum appear to reflect the degree of skin injury during NB-UVB phototherapy.
AuthorsK Kikuchi, K Wakamatsu, Y Tada, M Komine, S Ito, K Tamaki
JournalClinical and experimental dermatology (Clin Exp Dermatol) Vol. 33 Issue 6 Pg. 750-3 (Nov 2008) ISSN: 1365-2230 [Electronic] England
PMID18954414 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers
  • Cysteinyldopa
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers (blood)
  • Cysteinyldopa (blood)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Psoriasis (blood, radiotherapy)
  • Skin (radiation effects)
  • Statistics, Nonparametric
  • Time
  • Treatment Outcome
  • Ultraviolet Therapy (adverse effects)

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