Abstract | BACKGROUND: Ultraviolet (UV) B radiation from sunlight can result in tanning or burning of the skin. Narrowband UVB (NB-UVB), a relatively new light source that is not yet widely available, is effective for treating generalized psoriasis without the use of psoralens. AIMS: METHODS: In total, 11 Japanese patients with generalized psoriasis vulgaris received NB-UVB treatment five times per week, at an initial dose of 0.1 J/cm(2). The dose was increased by 10-20% per treatment for > 20 treatments. Serum samples were taken before and 3, 7, 10, 14 and 28 days after phototherapy. RESULTS: After 4 weeks of NB-UVB treatment, 9 of 11 patients were in remission, confirming the effectiveness of NB-UVB for treating Japanese patients with psoriasis. Two patients withdrew before day 28 because of other complications. Mean level of 5-S-CD in serum was significantly increased on day 7, 10 14 and 28 compared with the level before phototherapy and it peaked on day 10. CONCLUSIONS: Serum 5-S-CD levels were significantly increased by therapeutic UVB exposure. Sustained levels of 5-S-CD in serum appear to reflect the degree of skin injury during NB-UVB phototherapy.
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Authors | K Kikuchi, K Wakamatsu, Y Tada, M Komine, S Ito, K Tamaki |
Journal | Clinical and experimental dermatology
(Clin Exp Dermatol)
Vol. 33
Issue 6
Pg. 750-3
(Nov 2008)
ISSN: 1365-2230 [Electronic] England |
PMID | 18954414
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers
(blood)
- Cysteinyldopa
(blood)
- Female
- Humans
- Male
- Middle Aged
- Prospective Studies
- Psoriasis
(blood, radiotherapy)
- Skin
(radiation effects)
- Statistics, Nonparametric
- Time
- Treatment Outcome
- Ultraviolet Therapy
(adverse effects)
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