[Correlation of Epstein-Barr virus infection and childhood lymphoma].

Abstract

OBJECTIVE:

To investigate the correlation of Epstein-Barr virus (EBV) infection and childhood lymphoma.

METHODS:

Paraffin-embedded specimens of lymphoma collected between 1996 and 2005, including 36 Hodgkin lymphomas (HL) and 51 non-Hodgkin lymphomas (NHL), were included in this study. Paraffin-embedded specimens of reactive hyperplasia of lymph nodes (RL) collected during the same period were used as controls. Immunohistochemical (IHC) assay was used to detect EBV-LMP1 and in situ hybridization (ISH) to detect EBV-EBERs.

RESULTS:

EBV was detected in 72.2% (26/36) of the Hodgkin lymphomas, 15.7% (8/51) of the non-Hodgkin lymphomas and 33.3% (15/45) of the reactive hyperplasia of lymph nodes. There was a significant difference among Hodgkin lymphoma, non-Hodgkin lymphoma and RL (P = 0. 000).

CONCLUSION:

Childhood Hodgkin lymphoma is closely correlated with Epstein-Barr virus infection. However, the low rate of EBV infection detected in childhood non-Hodgkin lymphoma might be due to heterogeneous distribution of pathological types in this study.

• Authors: Zheng-De Xie, Lin Wang, Di Lu, Chun-Ju Zhou, Kun-Ling Shen
• Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] (Zhonghua Zhong Liu Za Zhi) Vol. 30 Issue 5 Pg. 365-7 (May 2008) ISSN: 0253-3766 [Print] China
• PMID: 18953837 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• EBV-associated membrane antigen, Epstein-Barr virus
• Epstein-Barr virus encoded RNA 1
• Epstein-Barr virus encoded RNA 2
• RNA, Viral
• Viral Matrix Proteins

Topics

• Child
• Child, Preschool
• Epstein-Barr Virus Infections (complications, metabolism)
• Female
• Herpesvirus 4, Human (isolation & purification)
• Hodgkin Disease (complications, metabolism, virology)
• Humans
• Lymphoma, Non-Hodgkin (complications, metabolism, virology)
• Male
• Pseudolymphoma (complications, metabolism, virology)
• RNA, Viral (metabolism)
• Viral Matrix Proteins (metabolism)