Chinese medicinal formula Guan-Xin-Er-Hao protects the heart against oxidative stress induced by acute ischemic myocardial injury in rats.

Abstract	Guan-Xin-Er-Hao (GXEH) is a Chinese medicine formula for treating ischemic heart diseases (IHD) and has a favorable effect. Our aim was to examine whether or not acute oral GXEH could protect the heart against myocardial infarction and apoptosis in acute myocardial ischemic rats. If so, we would explain the antioxidative mechanism involved. The left anterior descending coronary artery was occluded to induce myocardial ischemia in hearts of Sprague-Dawley rats. At the end of the 3h ischemic period (or 24h for infarct size), we measured the myocardial infarct size, myocardial apoptosis and the activities of antioxidative enzymes. GXEH reduced infarct size, myocardial apoptosis and the serum level of malondialdehyde (MDA), increased the activities of total antioxidant capacity (T-AOC), superoxide dismutase (SOD) and GSH-peroxidase (GPX) activities and the serum level of glutathione (GSH). GXEH exerts significant cardioprotective effects against acute ischemic myocardial injury in rats, likely through its antioxidation and antilipid peroxidative properties, and thus may be used as a promising agent for both prophylaxis and treatment of IHD.
Authors	F Qin, Y-X Liu, H-W Zhao, X Huang, P Ren, Z-Y Zhu
Journal	Phytomedicine : international journal of phytotherapy and phytopharmacology (Phytomedicine) Vol. 16 Issue 2-3 Pg. 215-21 (Mar 2009) ISSN: 1618-095X [Electronic] Germany
PMID	18951001 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antioxidants Drugs, Chinese Herbal Plant Extracts guan xin II Malondialdehyde Glutathione Peroxidase Superoxide Dismutase Glutathione
Topics	Animals Antioxidants (metabolism, pharmacology, therapeutic use) Apoptosis (drug effects) Drugs, Chinese Herbal (pharmacology, therapeutic use) Glutathione (metabolism) Glutathione Peroxidase (metabolism) Male Malondialdehyde (metabolism) Myocardial Infarction (prevention & control) Myocardial Ischemia (drug therapy, metabolism) Myocardium (metabolism) Oxidative Stress (drug effects) Phytotherapy Plant Extracts (pharmacology, therapeutic use) Rats Rats, Sprague-Dawley Superoxide Dismutase (metabolism)

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