Abstract | INTRODUCTION: MATERIALS AND METHODS: 2-[18F]Fluoro- A-85380 (2-FA) binds to nAChRs and with positron emission tomography (PET) imaging provides a composite measure of receptor density and ligand affinity. This study aimed to: (1) quantify nAChRs in vivo in 15 drug-naïve patients with mild AD before and after chronic treatment with galantamine, using 2-FA and PET, and (2) examine the relationship between treatment-induced changes in nAChRs and improvements in cognitive function. Participants were nonsmokers and underwent extensive cognitive testing and a PET scan after injection of approximately 200 MBq of 2-FA on two occasions (before and after 12 weeks, galantamine treatment). A 3-day washout period preceded the second scan. Brain regional 2-FA binding was assessed through a simplified estimation of distribution volume (DV(S)). RESULTS: Performance on global measures of cognition significantly improved following galantamine treatment (p < 0.05). This improvement extended to specific cognitive measures of language and verbal learning. No significant differences in nAChR DV(S) before and after galantamine treatment were found. The treatment-induced improvement in cognition was not correlated with regional or global nAChR DV(S), suggesting that changes in nAChRs may not be responsible for the improvements in cognition following galantamine in patients with mild AD.
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Authors | J R Ellis, P J Nathan, V L Villemagne, R S Mulligan, T Saunder, K Young, C L Smith, J Welch, M Woodward, K A Wesnes, G Savage, C C Rowe |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 202
Issue 1-3
Pg. 79-91
(Jan 2009)
ISSN: 1432-2072 [Electronic] Germany |
PMID | 18949462
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 2-fluoro-3-(2-azetidinylmethoxy)pyridine
- Azetidines
- Fluorine Radioisotopes
- Nootropic Agents
- Pyridines
- Radiopharmaceuticals
- Receptors, Nicotinic
- nicotinic receptor alpha4beta2
- Galantamine
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Topics |
- Aged
- Alzheimer Disease
(diagnostic imaging, metabolism, psychology)
- Arousal
(drug effects)
- Azetidines
- Cognition
(drug effects)
- Female
- Fluorine Radioisotopes
- Galantamine
(pharmacology)
- Humans
- Image Processing, Computer-Assisted
- Magnetic Resonance Imaging
- Male
- Neuropsychological Tests
- Nootropic Agents
(pharmacology)
- Positron-Emission Tomography
- Psychomotor Performance
(drug effects)
- Pyridines
- Radiopharmaceuticals
- Reaction Time
(drug effects)
- Receptors, Nicotinic
(drug effects)
- Space Perception
(drug effects)
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