HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Morphometric analysis of aortic coarctation: determination of the target vessel diameter required to relieve the pressure gradient.

AbstractBACKGROUND:
Little is known about the precise morphometric data of the aortic arch at which the transcatheter pressure gradient is relieved in patients with aortic coarctation (CoA).
METHODS AND RESULTS:
Twenty-nine morphometric data were obtained from patients with CoA including the body surface area (BSA) adjusted angiographic diameter of the narrowest vessel, the ratio of the angiographic diameter to that of the descending aorta and BSA-adjusted narrowest cross-sectional area (CSA) using intravascular ultrasound imaging. The transcatheter peak-to-peak pressure gradient of the aortic arch was measured using a manometer tipped catheter. A linear regression analysis showed CSA to have the strongest correlation with the pressure gradient (r=0.92, p=0.0002) among any pressure gradient group (n=10). A receiver-operating characteristic curve (ROC) analysis was performed to determine the morphometric cut-off point at which the pressure gradient occurs. CSA had the highest areas under the ROC (1.0) and the cut-off point of 81 mm2/m2 showed a sensitivity of 100% and specificity of 100% to predict the relief of a pressure gradient.
CONCLUSIONS:
In patients with CoA, the vessel size that can relieve a pressure gradient is a CSA of 81 mm2/m2 (10 x BSA0.5 mm in diameter). This data may provide useful information for catheter intervention and surgery.
AuthorsAtsuhito Takeda, Tomoaki Murakami
JournalCirculation journal : official journal of the Japanese Circulation Society (Circ J) Vol. 72 Issue 12 Pg. 1993-7 (Dec 2008) ISSN: 1346-9843 [Print] Japan
PMID18948670 (Publication Type: Journal Article)
Topics
  • Adolescent
  • Adult
  • Angioplasty, Balloon (instrumentation)
  • Aortic Coarctation (pathology, physiopathology, surgery)
  • Aortography
  • Blood Pressure
  • Body Surface Area
  • Child
  • Child, Preschool
  • Constriction, Pathologic
  • Female
  • Humans
  • Infant
  • Male
  • Predictive Value of Tests
  • Prosthesis Design
  • ROC Curve
  • Retrospective Studies
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Stents
  • Ultrasonography, Interventional
  • Vascular Surgical Procedures (instrumentation)
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: