PUVA-induced lymphomatoid papulosis in a patient with mycosis fungoides.

Abstract

The occurrence of lymphomatoid papulosis in patients with cutaneous lymphoma, particularly mycosis fungoides, has been described in medical literature. A 68-year-old woman affected by mycosis fungoides in the plaque stage noticed that multiple papulonodular lesions of lymphomatoid papulosis developed suddenly after a few sessions of PUVA therapy. The PUVA induction of lymphomatoid papulosis was confirmed by the appearance of new lesions after a second cycle of PUVA exposure on a limited area of the body. Complete regression of all PUVA-induced lymphomatoid papulosis lesions was achieved within a few weeks with oral prednisone and topical steroids. During the entire treatment the patches and plaques of mycosis fungoides persisted unchanged.

• Authors: P Wolf, L Cerroni, J Smolle, H Kerl
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 25 Issue 2 Pt 2 Pg. 422-6 (Aug 1991) ISSN: 0190-9622 [Print] United States
• PMID: 1894785 (Publication Type: Case Reports, Journal Article)

Topics

• Aged
• Eosinophils (pathology)
• Erythema (chemically induced, pathology)
• Female
• Hemorrhage (pathology)
• Histiocytes (pathology)
• Humans
• Lymphocytes (pathology)
• Mycosis Fungoides (drug therapy)
• PUVA Therapy (adverse effects)
• Skin Diseases (chemically induced, pathology)
• Skin Neoplasms (drug therapy)