Abstract |
Different types of hypoxia, including several new models, protect the brain against complete global ischemia. Hypoxic (stay in hermetic chamber without or with consumption of CO2 and H2O exhaled), circulatory ( bleeding), hematic ( injections of NaNO2, CoCl2, NiCl2) and tissue (histotoxic) hypoxia (K2-malonate injection) increases cerebral ischemic tolerance in early terms (in hours). Intracerebroventricular injections of NaNO2, CoCl2, NiCl2 and K2-malonate in nontoxic doses have weak effects. These substances act by peripheral mechanisms. Increased ischemic tolerance is accompanied by pronounced hypothermia which closely correlates with a neuroprotective effect. This shows using tolerant strategy.
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Authors | V I Kulinskiĭ, T V Gavrilina, L N Minakina, V Iu Kovtun |
Journal | Patologicheskaia fiziologiia i eksperimental'naia terapiia
(Patol Fiziol Eksp Ter)
2008 Jul-Sep
Issue 3
Pg. 18-20
ISSN: 0031-2991 [Print] Russia (Federation) |
PMID | 18946907
(Publication Type: English Abstract, Journal Article)
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Topics |
- Animals
- Brain Ischemia
(physiopathology, prevention & control)
- Female
- Hypothermia
(physiopathology)
- Ischemic Preconditioning
(methods)
- Male
- Mice
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