Renal function in pediatric liver transplantation: a long-term follow-up study.

Abstract

BACKGROUND:

Renal impairment is a frequent complication after orthotopic liver transplantation (OLT). However, most studies in children use inaccurate renal assessment based on serum creatinine, and long-term follow-up data are lacking. The purpose of this study was to determine incidence, determinants, and progression of long-term chronic renal insufficiency (CRI) in a single-center series of pediatric liver transplant recipients.

METHODS:

The true glomerular filtration rate was measured by inulin clearance before and serially after OLT in 69 consecutive patients followed more than 2 years after transplantation. Cumulative incidence of CRI (glomerular filtration rate<60 mL/min/1.73 m2) was determined using a Kaplan-Meier method. A Cox proportional hazard model was performed to identify predictors of CRI.

RESULTS:

The median age at OLT was 3.2 years. The median follow-up time after OLT was 9.3 years (interquartile range 6.3-11.9). At 10 years post-OLT, the cumulative incidence of CRI was 25%. In a multivariate Cox regression model, arterial hypertension during follow-up as time dependant variable (P=0.03), cyclosporine as primary immunosuppression (P=0.048), and liver diseases with potential renal involvement including inborn errors of metabolism, Alagille syndrome, and hepatic fibrosis (P=0.003) were associated with CRI.

CONCLUSIONS:

Renal function is a major concern long after OLT in children. Renal dysfunction post-OLT may be reduced by optimal control of arterial hypertension, immunosuppression protocols adapted to primary liver disease, and calcineurin inhibitor sparing regimen.

• Authors: Jérôme Harambat, Bruno Ranchin, Laurence Dubourg, Aurélia Liutkus, Aoumeur Hadj-Haïssa, Christine Rivet, Olivier Boillot, Alain Lachaux, Pierre Cochat
• Journal: Transplantation (Transplantation) Vol. 86 Issue 8 Pg. 1028-34 (Oct 27 2008) ISSN: 1534-6080 [Electronic] United States
• PMID: 18946339 (Publication Type: Journal Article)

Chemical References

• Immunosuppressive Agents
• Cyclosporine
• Inulin

Topics

• Adolescent
• Adult
• Child
• Child, Preschool
• Cyclosporine (adverse effects)
• Disease Progression
• Female
• Follow-Up Studies
• Glomerular Filtration Rate
• Humans
• Hypertension (complications)
• Immunosuppressive Agents (adverse effects)
• Incidence
• Infant
• Inulin
• Kaplan-Meier Estimate
• Liver Diseases (complications)
• Liver Transplantation (adverse effects)
• Male
• Proportional Hazards Models
• Renal Insufficiency, Chronic (diagnosis, epidemiology, etiology, physiopathology)
• Risk Assessment
• Risk Factors
• Severity of Illness Index
• Survivors
• Time Factors