CSF neurofilament and soluble TNF receptor 1 levels in subacute sclerosing panencephalitis.

Abstract

Neurofilament (NF) is one of the major cytoskeleton proteins of neurons and sTNFR1 is thought to reflect the true biological activity of TNF-alpha. To evaluate the levels of the heavy subunit of neurofilament (NF-H) and soluble TNF receptor 1 (sTNFR1) in cerebrospinal fluid (CSF) as biomarkers of clinical severity of subacute sclerosing panencephalitis (SSPE), concentrations of NF-H and sTNFR1 in CSF of 34 patients with SSPE and in control subjects were measured by ELISA. The CSF NF-H levels were significantly higher in patients with SSPE than in controls (p<0.0001), and those in patients in Jabbour stage III were significantly higher than in patients in stage II (p=0.015). The CSF sTNFR1 levels in SSPE patients were significantly higher than those in controls (p=0.004), but there were no significant differences in CSF sTNFR1 levels between patients in Jabbour stages II and III. There was a significant correlation between CSF NF-H and sTNFR1 levels in patients with SSPE (p=0.011). We suggest that CSF NF-H levels can be used as a marker of development of neuronal degeneration in SSPE, and that TNF-alpha modifies the neurodestructive pathogenesis in SSPE.

• Authors: Takeshi Matsushige, Takashi Ichiyama, Banu Anlar, Jun Tohyama, Keiko Nomura, Yushiro Yamashita, Susumu Furukawa
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 205 Issue 1-2 Pg. 155-9 (Dec 15 2008) ISSN: 0165-5728 [Print] Netherlands
• PMID: 18945496 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Immunoglobulin G
• Neurofilament Proteins
• Receptors, Tumor Necrosis Factor
• neurofilament protein H
• Etanercept

Topics

• Adolescent
• Biomarkers (cerebrospinal fluid)
• Case-Control Studies
• Chi-Square Distribution
• Child
• Child, Preschool
• Enzyme-Linked Immunosorbent Assay (methods)
• Etanercept
• Female
• Humans
• Immunoglobulin G (cerebrospinal fluid)
• Magnetic Resonance Imaging (methods)
• Male
• Neurofilament Proteins (cerebrospinal fluid)
• Receptors, Tumor Necrosis Factor
• Statistics, Nonparametric
• Subacute Sclerosing Panencephalitis (cerebrospinal fluid, pathology)
• Young Adult