Abstract | BACKGROUND:
Protease inhibitors (PIs) have been associated with metabolic complications. There is a trend to switch to simpler therapy to improve these disturbances. We report a case-series describing the effects in metabolic abnormalities in seven HIV-infected children, previously treated with protease inhibitor (PI) after switching to nevirapine. METHODS: RESULTS: Seven HIV-infected children were enrolled. Median age: 130 months (99,177). Median baseline CD4%: 32%. All had HIV-1 RNA < 50 copies/ml. Median length of preentry PI- therapy was 47 months (28, 91). Median age at the beginning of nevirapine was 120 months (99,177). Median decrease in cholesterol in 7.2 mmol/L was observed (P = 0.09), from baseline to 12 months. HDL-cholesterol increased in 5.1 mmol/L (P = 0.03) throughout the study period. No significant changes were observed in DXA with regard to body fat, but changes in total body bone mineral content and lean body content were significant. CD4% remained stable. All patients but one maintained viral load < 50 copies/ml at 12 months. The patient with virologic failure referred bad adherence. Children referred to take medication more easily. CONCLUSION: PI substitution with nevirapine improved lipid profile in our patients, although this strategy did not show significant changes in body fat or lipodystrophy.
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Authors | M Isabel Gonzalez-Tome, Jose Tomas Ramos Amador, M Jose Mellado Peña, M Luisa Navarro Gomez, Pablo Rojo Conejo, Pablo Martin Fontelos |
Journal | BMC infectious diseases
(BMC Infect Dis)
Vol. 8
Pg. 144
(Oct 22 2008)
ISSN: 1471-2334 [Electronic] England |
PMID | 18945352
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Protease Inhibitors
- Reverse Transcriptase Inhibitors
- Nevirapine
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Topics |
- Absorptiometry, Photon
- Adipose Tissue
(diagnostic imaging, drug effects)
- Adolescent
- Antiretroviral Therapy, Highly Active
(methods)
- CD4 Lymphocyte Count
- Child
- Female
- HIV Infections
(drug therapy, virology)
- HIV-1
(isolation & purification)
- Humans
- Hyperlipidemias
(chemically induced)
- Lipodystrophy
(chemically induced)
- Male
- Nevirapine
(therapeutic use)
- Protease Inhibitors
(adverse effects, therapeutic use)
- Reverse Transcriptase Inhibitors
(therapeutic use)
- Treatment Outcome
- Viral Load
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