Abstract | BACKGROUND: The gamma-aminobutyric acid ( GABA) system is implicated in the neurobiological actions of ethanol, and pharmacological agents that increase the activity of this system have been proposed as potential treatments for alcohol use disorders. As ethanol has its own GABA mimetic properties, it is critical to determine the mechanism by which GABAergic drugs may reduce the response to ethanol (i.e., via an inhibition or an accentuation of the neurobiological effects of ethanol). METHODS: RESULTS: CONCLUSIONS:
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Authors | Sarah E Holstein, Lauren Dobbs, Tamara J Phillips |
Journal | Alcoholism, clinical and experimental research
(Alcohol Clin Exp Res)
Vol. 33
Issue 1
Pg. 108-20
(Jan 2009)
ISSN: 1530-0277 [Electronic] England |
PMID | 18945218
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- GABA-A Receptor Agonists
- GABA-B Receptor Agonists
- Nipecotic Acids
- Oximes
- Receptors, GABA-A
- Receptors, GABA-B
- NNC 711
- Muscimol
- Ethanol
- Baclofen
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Topics |
- Animals
- Ataxia
(chemically induced, metabolism, physiopathology)
- Baclofen
(pharmacology)
- Dose-Response Relationship, Drug
- Ethanol
(antagonists & inhibitors, toxicity)
- GABA-A Receptor Agonists
- GABA-B Receptor Agonists
- Male
- Mice
- Mice, Mutant Strains
- Motor Activity
(drug effects, physiology)
- Muscimol
(pharmacology)
- Nipecotic Acids
(pharmacology)
- Oximes
(pharmacology)
- Receptors, GABA-A
(metabolism)
- Receptors, GABA-B
(metabolism)
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