[New therapeutic alternatives in migraine prophylaxis using histamine H3 receptor agonists].

Subcutaneous histamine at low concentrations interacts with H3-receptors and may constitute a new therapeutic drug in migraine prophylaxis. It acts by limiting the excessive inflammatory response involved in migraine pathophysiology.
Describe the results of a 15-year trial administering histamine at low concentrations.
Different study designs were used with subcutaneous histamine (10 microg/ml in Evan's solution) twice weekly, with an initial administration of microg (0.1 ml) and gradually increasing the dose to 10 microg (1.0 ml) over a 12-week period together with placebo, sodium valproate and topiramate. A Friedman-type rank ANOVA test was used to assess the difference between basal values and different design outcomes.
Data recorded during the 12-week period showed a significant reduction in variables from both treatment groups (histamine) compared with basaline stage results (p < 0.001). The histamine group reported a reduction of headache frequency (50%), decrease in pain intensity (51%), length of migraine attacks (45%) and painkiller use (52%).
The present study provides evidence on the safety and efficiency of subcutaneous histamine administered at a dose of 1-10 microg twice weekly. This treatment constitutes a new therapeutic alternative, and provides a clinical and pharmacological basis for the use of H3 histaminergic agonists in migraine prophylaxis.
AuthorsRebeca O Millán-Guerrero, Rebeca Isais-Millán
JournalGaceta médica de México (Gac Med Mex) 2008 Jul-Aug Vol. 144 Issue 4 Pg. 291-5 ISSN: 0016-3813 [Print] Mexico
Vernacular TitleNueva alternativa terapéutica en profilaxis de migraña con histamina como agonista de receptores H3.
PMID18942262 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Histamine Agonists
  • Adult
  • Female
  • Histamine Agonists (therapeutic use)
  • Humans
  • Male
  • Migraine Disorders (prevention & control)

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