[Atypical pulmonary carcinoid tumor with abnormal elevation of serum gastrin-releasing peptide precursor: report of a case].

Abstract

We report a rare case of atypical pulmonary carcinoid tumor accompanied by elevation of serum gastrin-releasing peptide precursor (ProGRP). A 55-year-old male presented to our hospital with a history of bloody sputum. The level of serum ProGRP was elevated to 781 pg/ml (normal < 46 pg/ml). Chest computed tomography (CT) revealed a solitary pulmonary tumor in the left lower lobe with sub-carinal lymph node enlargement. Transbronchial lung biopsy showed a pulmonary carcinoid, therefore left lower lobectomy with mediastinal lymph node dissection was performed. ProGRP decreased to normal level 1 month after operation. Histopathological diagnosis showed an atypical pulmonary carcinoid tumor.

• Authors: T Endo, T Hasegawa, Y Tezuka, Y Kanai, S Otani, S Yamamoto, K Tetsuka, Y Sato, S Endo, Y Sohara
• Journal: Kyobu geka. The Japanese journal of thoracic surgery (Kyobu Geka) Vol. 61 Issue 11 Pg. 993-5 (Oct 2008) ISSN: 0021-5252 [Print] Japan
• PMID: 18939440 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Biomarkers, Tumor
• Peptide Fragments
• Recombinant Proteins
• pro-gastrin-releasing peptide (31-98)

Topics

• Biomarkers, Tumor (blood)
• Biopsy
• Carcinoid Tumor (diagnosis, pathology, surgery)
• Humans
• Lung Neoplasms (diagnosis, pathology, surgery)
• Lymph Node Excision
• Male
• Middle Aged
• Peptide Fragments (blood)
• Pneumonectomy
• Recombinant Proteins (blood)
• Treatment Outcome