Cytotoxic cucurbitane-type triterpenoids from Elaeocarpus hainanensis.

Abstract

Bioassay-guided fractionation of the crude extract of Elaeocarpus hainanensis (Elaeocarpaceae), using the proliferation of non-small cell lung cancer A549/ATCC and human hepatocellular carcinoma BEL-7402 cells as a monitor, led to the isolation of ten cucurbitane-type triterpenoids, including three new compounds (1-3) and seven known compounds (4-10). Their structures were determined on the basis of spectroscopic analyses, chemical methods, and comparison with spectroscopic data in literature. The two known compounds, cucurbitacins D (5) and I (10) were found to exhibit the strongest cytotoxicity against A549/ATCC and BEL-7402 cells in vitro with IC50 values of less than 1 microM.

• Authors: Dahai Meng, Shigao Qiang, Liguang Lou, Weimin Zhao
• Journal: Planta medica (Planta Med) Vol. 74 Issue 14 Pg. 1741-4 (Nov 2008) ISSN: 0032-0943 [Print] Germany
• PMID: 18937166 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Triterpenes

Topics

• Antineoplastic Agents, Phytogenic (chemistry, pharmacology)
• Cell Line
• Cell Proliferation (drug effects)
• Elaeocarpaceae (chemistry)
• Humans
• Molecular Structure
• Plant Components, Aerial (chemistry)
• Triterpenes (chemistry, pharmacology)