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Successful surgical management of giant condyloma acuminatum (Buschke-Löwenstein tumor) in the genitoanal region: a case report and evaluation of current therapies.

Abstract
Giant condyloma acuminatum (GCA; Buschke-Lowenstein tumor) is a human-papillomavirus-induced cauliflower-like tumor of the genitoanal region. It is characterized by its size, capability of local infiltration and high recurrence rate. We report on a 50-year-old patient presenting with a maximum finding of GCA with deep infiltration into the adductor and perineal musculature, the scrotum, the penis and the para-rectum. After performing a temporary loop colostomy, the tumor was removed by wide radical excision following plastic reconstruction with a myocutaneous gracilis flap. During a follow-up period of more than 5 years, no recurrence developed. Many treatment strategies (e.g. chemotherapy, radiation) have been published in the literature. Most authors recommend the radical surgical excision, allowing a complete histological examination and assessment of tumor-free resection margins. Despite the benign histological pattern of GCA in most cases, transformations into verrucous carcinoma and squamous-cell carcinoma have been described. In our case, the GCA seems to represent a continuum between normal condyloma acuminatum and an initial verrucous carcinoma.
AuthorsP Gholam, A Enk, W Hartschuh
JournalDermatology (Basel, Switzerland) (Dermatology) Vol. 218 Issue 1 Pg. 56-9 ( 2009) ISSN: 1421-9832 [Electronic] Switzerland
PMID18936533 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright 2008 S. Karger AG, Basel.
Topics
  • Anus Neoplasms (pathology, surgery, virology)
  • Condylomata Acuminata (pathology, surgery, virology)
  • Human papillomavirus 6 (isolation & purification)
  • Humans
  • Male
  • Middle Aged
  • Papillomavirus Infections (pathology, surgery, virology)
  • Penile Neoplasms (pathology, surgery, virology)
  • Skin (pathology)
  • Surgical Flaps
  • Treatment Outcome
  • Urologic Surgical Procedures, Male

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