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Estrogen receptor beta (ERbeta) in endometrial simple hyperplasia and endometrioid carcinoma.

AbstractAIMS:
The aim of this study was to analyze the expression of estrogen receptor (ER) beta in endometrioid carcinoma in comparison to non-neoplastic endometrium.
METHODS:
Fifty-seven histopathologically confirmed non-neoplastic endometria (22 proliferative phase, 15 secretory phase, and 20 simple hyperplasia without atypia), and 26 cases of endometrioid carcinoma were studied. The ERbeta/ERalpha transcript ratio was determined by semiquantitative reverse transcription-polymerase chain reaction. The receptor protein expression was evaluated by immunohistochemistry using the Allred Scoring System.
RESULTS:
Decreased expression of ERbeta, ERalpha, and progesterone receptor proteins was observed in endometrioid carcinoma compared with proliferative endometrium and simple hyperplasia (P<0.01, Mann-Whitney U test). Within the group of endometrioid carcinoma, a correlation of increased ERbeta expression with tumors exhibiting > or =50% myoinvasion (P=0.034) was observed, whereas there was no correlation with the grade of tumor (P=0.314). There was a significant association of ERbeta with ERalpha expression in both non-neoplastic and neoplastic endometrium indicating interdependence of expression. Progesterone receptor protein expression was influenced by ERalpha levels and not by ERbeta as shown by regression analysis in non-neoplastic and neoplastic endometrium.
CONCLUSIONS:
Thus, ERbeta alterations are important in endometrioid carcinoma. The relationship of ERbeta expression to myoinvasion warrants further investigation.
AuthorsDimple Chakravarty, Radhika Srinivasan, Sujata Ghosh, Arvind Rajwanshi, Sarala Gopalan
JournalApplied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry (Appl Immunohistochem Mol Morphol) Vol. 16 Issue 6 Pg. 535-42 (Dec 2008) ISSN: 1533-4058 [Electronic] United States
PMID18931615 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Estrogen Receptor alpha
  • Estrogen Receptor beta
  • Receptors, Progesterone
Topics
  • Adult
  • Aged
  • Carcinoma, Endometrioid (metabolism, pathology)
  • Endometrial Hyperplasia (metabolism, pathology)
  • Endometrial Neoplasms (metabolism, pathology)
  • Estrogen Receptor alpha (genetics, metabolism)
  • Estrogen Receptor beta (genetics, metabolism)
  • Female
  • Gene Expression Regulation, Neoplastic (genetics)
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Receptors, Progesterone (genetics, metabolism)
  • Reverse Transcriptase Polymerase Chain Reaction
  • Statistics as Topic

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