[A case of multiple liver metastases of sigmoid colon cancer responding well to UFT+Leucovorin therapy].

Abstract

The subject was a 75-year-old female. For the treatment of multiple liver metastases from sigmoid colon cancer, the administration of UFT(300 mg/day)and oral Leucovorin(75 mg/day)was initiated after a resection of the sigmoid colon. A decrease in the liver metastases was observed in a CT scan 4 months after the start of this administration, and the disappearance of the metastatic focus in the liver was confirmed at 10 months thereafter. The administration of UFT and oral Leucovorin was continued for 2 months. Thereafter, at 12 months after the start of this administration, was continued with only the administration of UFT(300 mg/day)for 1 year. Now, 26 months have passed since the liver metastases disappeared and no recurrence has been found, even within the abdominal cavity. The condition of the patient has been excellent. The subject of this study was an elderly person, but an excellent QOL was secured without any adverse events, and the chemotherapy regimen could be maintained for 2 years. These findings suggest that UFT and oral Leucovorin can be expected to have an excellent therapeutic effect as an oral chemotherapeutic agent.

• Authors: Toshimasa Ishii, Hiroyuki Komoriyama, Shinya Mikami, Kazuhiro Ashikawa, Takehito Ohtsubo
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 35 Issue 10 Pg. 1775-7 (Oct 2008) ISSN: 0385-0684 [Print] Japan
• PMID: 18931587 (Publication Type: Case Reports, Journal Article)

Chemical References

• Tegafur
• Uracil
• Leucovorin

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Female
• Humans
• Leucovorin (therapeutic use)
• Liver Neoplasms (diagnostic imaging, drug therapy, secondary)
• Magnetic Resonance Imaging
• Radiography
• Sigmoid Neoplasms (diagnostic imaging, drug therapy, pathology, surgery)
• Tegafur (therapeutic use)
• Ultrasonography
• Uracil (therapeutic use)