Abstract | BACKGROUND: METHODS: In this prospective, blind, randomized trial we recorded postoperative analgesic requirements (mg of morphine) and pain scores (visual analog scale in mm) 2, 4, 8, and 24 h postoperatively in patients undergoing abdominal hysterectomy or myomectomy under sevoflurane, desflurane or propofol anesthesia, titrated to maintain Bispectral Index values between 35 and 45. Pain scores were also recorded immediately after transfer to the postanesthesia care unit. RESULTS: Cumulative morphine consumption did not differ among the three groups 2, 4, 8, or 24 h postoperatively (P = 0.50). The morphine consumed within 24 h postoperatively was 28 +/- 13.8 mg in the sevoflurane group, 25 +/- 11.7 mg in the desflurane group and 27 +/- 16.1 mg in the propofol group. The visual analog scale values at rest or after cough immediately after patient transport to the postanesthesia care unit and 2, 4, 8, and 24 h after surgery did not differ among the three groups (P = 0.40, 0.39, 0.50, 0.47, 0.06 at rest and P = 0.67, 0.45, 0.22, 0.26, 0.29 after cough respectively). CONCLUSION:
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Authors | Argyro Fassoulaki, Aikaterini Melemeni, Anteia Paraskeva, Ioanna Siafaka, Constantine Sarantopoulos |
Journal | Anesthesia and analgesia
(Anesth Analg)
Vol. 107
Issue 5
Pg. 1715-9
(Nov 2008)
ISSN: 1526-7598 [Electronic] United States |
PMID | 18931237
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Analgesics
- Analgesics, Opioid
- Anesthetics, Inhalation
- Anesthetics, Intravenous
- Methyl Ethers
- Sevoflurane
- Morphine
- Desflurane
- Isoflurane
- Propofol
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Topics |
- Adult
- Analgesia, Patient-Controlled
(methods)
- Analgesics
(therapeutic use)
- Analgesics, Opioid
(administration & dosage, therapeutic use)
- Anesthesia Recovery Period
- Anesthesia, Intravenous
(methods)
- Anesthetics, Inhalation
(therapeutic use)
- Anesthetics, Intravenous
(therapeutic use)
- Desflurane
- Double-Blind Method
- Female
- Humans
- Hysterectomy
- Isoflurane
(analogs & derivatives, therapeutic use)
- Methyl Ethers
(therapeutic use)
- Middle Aged
- Morphine
(administration & dosage, therapeutic use)
- Pain, Postoperative
(drug therapy, epidemiology)
- Propofol
(therapeutic use)
- Sevoflurane
- Uterine Neoplasms
(surgery)
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