Abstract | BACKGROUND & AIMS: METHODS: We conducted 3 retrospective case-control studies nested within the cohort of diabetic patients who were cared for within the Kaiser Permanente of Northern California system from 1994 to 2005. Case subjects were those with colonic neoplasia identified at the time of colonoscopy (study 1), sigmoidoscopy (study 2), or at follow-up lower endoscopy (study 3). Controls had no neoplasia identified at the endoscopic examination. A minimum of 1 year of therapy was used to define medication exposure. RESULTS: Fourteen thousand eighty-six patients were included. Among patients undergoing colonoscopy, there was an inverse association between thiazolidinedione exposure and prevalence of neoplasia (adjusted odd ratio [OR], 0.73; 95% confidence interval [CI], 0.57-0.92); however, this was not evident among patients without anemia (adjusted OR, 0.97; 95% CI, 0.64-1.49). Significant associations between any or long-term thiazolidinedione use and colonic neoplasia were not observed among patients undergoing sigmoidoscopy or serial lower endoscopies. CONCLUSIONS:
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Authors | James D Lewis, Angela M Capra, Ninah S Achacoso, Assiamira Ferrara, Theodore R Levin, Charles P Quesenberry Jr, Laurel A Habel |
Journal | Gastroenterology
(Gastroenterology)
Vol. 135
Issue 6
Pg. 1914-23, 1923.e1
(Dec 2008)
ISSN: 1528-0012 [Electronic] United States |
PMID | 18930061
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Research Support, N.I.H., Extramural)
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Chemical References |
- Hypoglycemic Agents
- Ligands
- Thiazolidinediones
- 2,4-thiazolidinedione
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Topics |
- Aged
- California
(epidemiology)
- Colonic Neoplasms
(diagnosis, epidemiology, etiology)
- Colonoscopy
- Diabetes Mellitus, Type 1
(complications, drug therapy, epidemiology)
- Diabetes Mellitus, Type 2
(complications, drug therapy, epidemiology)
- Female
- Follow-Up Studies
- Humans
- Hypoglycemic Agents
(therapeutic use)
- Ligands
- Male
- Middle Aged
- Prevalence
- Retrospective Studies
- Risk Factors
- Surveys and Questionnaires
- Thiazolidinediones
(therapeutic use)
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