Abstract | OBJECTIVE: STUDY DESIGN: The expression of these mediators was evaluated by means of immunohistochemistry. RESULTS: All specimens demonstrated positive immunoreactivity to RANK, RANKL, and OPG. The quantification of these mediators in epithelium revealed a similar pattern of expression for RANKL and OPG in CCOT, AOT, CEOT, and AF. With regard to stromal/mesenchymal cells, the majority of AOT and CCOT cases showed a higher content of OPG than RANKL, whereas CEOT, OM, and especially AF had a tendency to present a greater content of RANKL than OPG. CONCLUSION: Our data indicate that the CCOT, AOT, CEOT, OM, and AF cell constituents express key regulators of bone metabolism that might locally modulate tumor-associated bone resorption.
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Authors | Flávia R Andrade, Débora P Sousa, Elismauro F Mendonça, Tarcília A Silva, Vanessa S Lara, Aline C Batista |
Journal | Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
(Oral Surg Oral Med Oral Pathol Oral Radiol Endod)
Vol. 106
Issue 4
Pg. 548-55
(Oct 2008)
ISSN: 1528-395X [Electronic] United States |
PMID | 18928898
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Osteoprotegerin
- RANK Ligand
- Receptor Activator of Nuclear Factor-kappa B
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Topics |
- Adult
- Alveolar Bone Loss
(etiology, metabolism)
- Female
- Humans
- Immunohistochemistry
- Jaw Neoplasms
(chemistry, complications, metabolism)
- Male
- Odontogenic Tumors
(chemistry, complications, metabolism)
- Osteoclasts
(metabolism)
- Osteolysis
(etiology, metabolism)
- Osteoprotegerin
(biosynthesis)
- RANK Ligand
(biosynthesis)
- Receptor Activator of Nuclear Factor-kappa B
(biosynthesis)
- Young Adult
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