Abstract | BACKGROUND AND PURPOSE: METHODS: We recruited 80 patients hospitalized for acute ischemic stroke. Stroke severity was measured by the National Institutes of Health Stroke Scale (NIH-SS). Infarct volume was determined by MRI. Platelet C4d was measured by flow cytometry. RESULTS: Mean age was 57.9 years (range: 24.6 to 86.8 years), 58% were male, and 91% were white. Eight patients (10%) with acute ischemic stroke were platelet C4d-positive, which was significantly higher in prevalence compared to healthy controls (0%, P<0.0001) and non-SLE patients with immune/inflammatory disease (2%, P=0.004). The median NIH-SS score and infarct volume for acute stroke patients were 6 (interquartile range [IQR]: 2 to 13) and 3.4 cc (IQR: 1.1 to 16.6), respectively. Platelet C4d-positive patients were more likely to have a severe stroke compared to those with negative platelet C4d (NIH-SS median: 17.5 versus 5, P=0.003). Positive platelet C4d was independently associated with stroke severity (P=0.03) after controlling for age, anticardiolipin antibody (aCL) status, and total anterior circulation of stroke involvement, and also with infarct volume (P=0.005) after controlling for age, aCL status, and old stroke by MRI. CONCLUSIONS:
|
Authors | Nidhi Mehta, Ken Uchino, Saeed Fakhran, M Abdus Sattar, Barton F Branstetter 4th, Karen Au, Jeannine S Navratil, Barbara Paul, Melissa Lee, Katie M Gallagher, Susan Manzi, Joseph M Ahearn, Amy H Kao |
Journal | Stroke
(Stroke)
Vol. 39
Issue 12
Pg. 3236-41
(Dec 2008)
ISSN: 1524-4628 [Electronic] United States |
PMID | 18927458
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antibodies, Anticardiolipin
- Biomarkers
- Fibrinolytic Agents
- Peptide Fragments
- Platelet Aggregation Inhibitors
- Complement C4b
- complement C4d
|
Topics |
- Acute Disease
- Aged
- Antibodies, Anticardiolipin
(blood)
- Arthritis, Rheumatoid
(blood, complications, immunology)
- Biomarkers
- Blood Platelets
(chemistry)
- Brain Ischemia
(blood, drug therapy, immunology, pathology)
- Cardiovascular Diseases
(blood, immunology)
- Comorbidity
- Complement C4b
- Female
- Fibrinolytic Agents
(therapeutic use)
- Humans
- Inflammation
(blood, immunology)
- Lupus Erythematosus, Systemic
(blood, complications, immunology)
- Male
- Middle Aged
- Peptide Fragments
(blood)
- Platelet Aggregation Inhibitors
(therapeutic use)
- Rheumatic Diseases
(blood, immunology)
- Risk Factors
- Severity of Illness Index
- Thrombolytic Therapy
|