Abstract |
A 79-year-old woman presented with dystonic posturing of the right leg while walking and an action tremor of her hands, both of which were levodopa responsive. She subsequently developed gait freezing. However, there was neither generalised bradykinesia nor rigidity. Structural imaging showed no significant changes, and a dopamine transporter scan was normal. She subsequently required rapidly escalating doses of levodopa in order to achieve symptom control, raising concerns over the possible development of a dopamine dysregulation syndrome. Issues raised included the difficulties of managing patients with a rare diagnosis and the role of dopaminergic medication with the potential for abuse.
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Authors | Adam Harper, Mark Bayliss, Romi Saha, Amanda Scutt, Angus Nisbet |
Journal | Age and ageing
(Age Ageing)
Vol. 37
Issue 6
Pg. 719-20
(Nov 2008)
ISSN: 1468-2834 [Electronic] England |
PMID | 18922834
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antiparkinson Agents
- Benzothiazoles
- Dopamine Agents
- Levodopa
- Pramipexole
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Topics |
- Aged
- Antiparkinson Agents
(therapeutic use)
- Benzothiazoles
(therapeutic use)
- Diagnosis, Differential
- Dopamine Agents
(therapeutic use)
- Drug Therapy, Combination
- Dystonia
(complications, diagnosis, drug therapy)
- Female
- Gait Disorders, Neurologic
(complications, diagnosis)
- Humans
- Levodopa
(therapeutic use)
- Pramipexole
- Tremor
(complications, diagnosis)
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