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Defective Fc receptor-mediated clearance in patients with primary biliary cirrhosis.

Abstract
Fc receptor-mediated clearance of immunoglobulin G-coated autologous erythrocytes was studied in patients with primary biliary cirrhosis (n = 14), alcoholic liver cirrhosis (n = 5) and healthy reference individuals (n = 14). The mean half-life of the sensitized erythrocytes was significantly prolonged in patients with primary biliary cirrhosis (85 +/- 25 minutes; P less than 0.001) compared with the corresponding value in patients with alcoholic cirrhosis (16 +/- 2 minutes) and healthy reference individuals (20 +/- 5 minutes), respectively. No correlation between clearance rate and age, liver histopathology, or serum levels of bilirubin, aminotransferases, immunoglobulin G, immunoglobulin A, and Clq binding or C3-containing immune complexes was found. The results presented here indicate a profound disturbance of Fc receptor-mediated immune clearance function in patients with primary biliary cirrhosis.
AuthorsK N Ekdahl, L Lööf, A Nyberg, U R Nilsson, B Nilsson
JournalGastroenterology (Gastroenterology) Vol. 101 Issue 4 Pg. 1076-82 (Oct 1991) ISSN: 0016-5085 [Print] United States
PMID1889700 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigen-Antibody Complex
  • Immunoglobulin G
  • Receptors, Fc
Topics
  • Antigen-Antibody Complex (immunology)
  • Erythrocyte Aging
  • Erythrocytes (immunology)
  • Female
  • Flow Cytometry
  • Humans
  • Immunoglobulin G
  • Liver Cirrhosis, Alcoholic (immunology)
  • Liver Cirrhosis, Biliary (immunology)
  • Male
  • Middle Aged
  • Mononuclear Phagocyte System (immunology)
  • Phagocytosis
  • Receptors, Fc (immunology)

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