The effects of renzapride, a novel prokinetic agent, in diabetic gastroparesis.

Abstract

Gastric emptying was measured in 9 diabetic patients with autonomic neuropathy (Group 1) and 8 normal controls (Group 2) on 4 occasions after swallowing placebo, 0.5, 1.0 or 2.0 mg of the newly developed prokinetic drug renzapride given double-blind and in random order. The liquid component of the test meal was labelled with In113m and the solid with Tc99m. Liquid emptying was uni-exponential. Solid emptying comprised an initial lag phase, followed by a linear component. Following placebo, the mean lag phase of solid emptying was 40 +/- 7 (S.E.M.) min in Group 1 and 16 +/- 2 min in Group 2 (P less than 0.01). In Group 1 subjects renzapride reduced the mean lag phase by 20-26 min at all doses (P less than 0.01). No effect was seen in Group 2. The linear rate of solid emptying was similar in both groups (0.9 +/- 0.1 and 1.0 +/- 0.2%/min) and was not altered by renzapride. Mean liquid t1/2 was similar in Groups 1 and 2 after placebo (30 +/- 6 and 29 +/- 4 min, respectively) and was decreased with increasing doses of renzapride in both groups. No adverse effects were encountered in any subjects. Renzapride may be useful in the treatment of diabetic gastroparesis.

• Authors: A D Mackie, C Ferrington, S Cowan, M V Merrick, J D Baird, K R Palmer
• Journal: Alimentary pharmacology & therapeutics (Aliment Pharmacol Ther) Vol. 5 Issue 2 Pg. 135-42 (Apr 1991) ISSN: 0269-2813 [Print] England
• PMID: 1888816 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Benzamides
• Bridged Bicyclo Compounds
• Bridged Bicyclo Compounds, Heterocyclic
• Serotonin Antagonists
• renzapride

Topics

• Adult
• Aged
• Autonomic Nervous System Diseases (drug therapy, physiopathology)
• Benzamides (adverse effects, therapeutic use)
• Bridged Bicyclo Compounds (adverse effects, therapeutic use)
• Bridged Bicyclo Compounds, Heterocyclic
• Diabetic Neuropathies (drug therapy, physiopathology)
• Double-Blind Method
• Female
• Gastric Emptying (drug effects)
• Humans
• Male
• Middle Aged
• Serotonin Antagonists (adverse effects, therapeutic use)
• Stomach Diseases (drug therapy, etiology, physiopathology)