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O6-methylguanine-DNA methyltransferase and human cancer chemotherapy.

Abstract
Two kinds of human tumor cell strains having different activity of O6-methylguanine-DNA methyltransferase (O6-MT) were transplanted into nude mice. Then the mice were injected intraperitoneally with bifunctional alkylating agent 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU). The tumors with low O6-MT activity were quickly suppressed or cured. The result suggests that some tumors, if provisionally determined with low O6-MT activity, might be efficiently cured by treatment with ACNU. This probably opens a new way for human cancer chemotherapy.
AuthorsY P Zhang, D W Wang, Y N Chen, Y Wu, H Y Xu, G C Fan, X B Bai, X M Wang, J X Li, L Zhu
JournalScience in China. Series B, Chemistry, life sciences & earth sciences (Sci China B) Vol. 34 Issue 6 Pg. 675-82 (Jun 1991) ISSN: 1001-652X [Print] China
PMID1888434 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Bacterial Proteins
  • Escherichia coli Proteins
  • Transcription Factors
  • Nimustine
  • Ada protein, E coli
  • O(6)-Methylguanine-DNA Methyltransferase
Topics
  • Animals
  • Bacterial Proteins (metabolism)
  • Escherichia coli Proteins
  • HeLa Cells
  • Humans
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Neoplasm Transplantation
  • Neoplasms, Experimental (drug therapy, enzymology)
  • Nimustine (therapeutic use)
  • O(6)-Methylguanine-DNA Methyltransferase
  • Transcription Factors
  • Tumor Stem Cell Assay

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