Abstract |
Two kinds of human tumor cell strains having different activity of O6-methylguanine-DNA methyltransferase (O6-MT) were transplanted into nude mice. Then the mice were injected intraperitoneally with bifunctional alkylating agent 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride ( ACNU). The tumors with low O6-MT activity were quickly suppressed or cured. The result suggests that some tumors, if provisionally determined with low O6-MT activity, might be efficiently cured by treatment with ACNU. This probably opens a new way for human cancer chemotherapy.
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Authors | Y P Zhang, D W Wang, Y N Chen, Y Wu, H Y Xu, G C Fan, X B Bai, X M Wang, J X Li, L Zhu |
Journal | Science in China. Series B, Chemistry, life sciences & earth sciences
(Sci China B)
Vol. 34
Issue 6
Pg. 675-82
(Jun 1991)
ISSN: 1001-652X [Print] China |
PMID | 1888434
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bacterial Proteins
- Escherichia coli Proteins
- Transcription Factors
- Nimustine
- Ada protein, E coli
- O(6)-Methylguanine-DNA Methyltransferase
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Topics |
- Animals
- Bacterial Proteins
(metabolism)
- Escherichia coli Proteins
- HeLa Cells
- Humans
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Neoplasm Transplantation
- Neoplasms, Experimental
(drug therapy, enzymology)
- Nimustine
(therapeutic use)
- O(6)-Methylguanine-DNA Methyltransferase
- Transcription Factors
- Tumor Stem Cell Assay
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