[The clinical and immunogenetic characteristics of reactive arthritis in children].

Abstract

Altogether 52 children suffering from reactive arthritis were placed under observation. In 45 patients arthritis developed after nasopharyngeal infection and was marked by a favourable course with a rapid positive dynamics. 7 children with a history of intestinal infection manifested Reiter's syndrome; in these children arthritis was characterized by a grave and prolonged course and by a high laboratory activity. HLA A10 (RR = 2.7), B27 (RR = 2.5) and DR2 (RR = 2.19) antigen were detected significantly more frequently in ReA patients who suffered nasopharyngeal infection. In children with Reiter's syndrome, the genetic markers of predisposition to the disease were HLA A10 (RR = 5.93) and B27 (RR = 149.1) antigens.

• Authors: V A Artamonov, S Akhmadi, I S Polianskaia
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 63 Issue 5 Pg. 22-4 ( 1991) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Nekotorye klinicheskie i immunogeneticheskie osobennosti reaktivnykh artritov u deteĭ.
• PMID: 1887405 (Publication Type: Journal Article)

Chemical References

• HLA Antigens
• PHB2 protein, human
• Prohibitins

Topics

• Adolescent
• Arthritis, Infectious (diagnosis, genetics, immunology)
• Arthritis, Reactive (diagnosis, genetics, immunology)
• Child
• Child, Preschool
• Disease Susceptibility
• Female
• HLA Antigens (analysis, genetics)
• Humans
• Male
• Prohibitins