Chalcones and their potential role in inflammation.

Abstract

Chalcones are a group of phenolic compounds which possess a wide variety of cytoprotective and modulatory functions. They have been shown to possess antioxidant, oxygen scavenging and anti-inflammatory properties in a variety of experimental systems and can trigger the intracellular cascade of protective pathways offering a promising stratagem for therapeutic applications. In this research we will review the anti-inflammatory effect of chalcone derivatives and new approaches.

• Authors: C Kontogiorgis, M Mantzanidou, D Hadjipavlou-Litina
• Journal: Mini reviews in medicinal chemistry (Mini Rev Med Chem) Vol. 8 Issue 12 Pg. 1224-42 (Oct 2008) ISSN: 1389-5575 [Print] Netherlands
• PMID: 18855737 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Inflammatory Agents
• Antioxidants
• Chalcones
• Free Radical Scavengers
• Leukotriene B4
• Phenol
• Oxygen

Topics

• Animals
• Anti-Inflammatory Agents (pharmacology)
• Antioxidants (metabolism)
• Chalcones (pharmacology)
• Chemistry, Pharmaceutical (methods)
• Drug Design
• Free Radical Scavengers
• Humans
• Inflammation
• Leukotriene B4 (chemistry)
• Models, Biological
• Models, Chemical
• Neutrophils (metabolism)
• Oxygen (chemistry)
• Phenol (chemistry)