Abstract | OBJECTIVE: METHODS: Twenty-four patients were randomized equally into three groups. All were treated with the basic conventional treatment by cognition-behavior therapy with assistance of lactein 3 tablets thrice a day. Additionally, 24 g of SJG was given three times a day to group A, and the same dosage of SJG and Smecta 15 g thrice a day was given to group B, while no additional treatment was given to the control group. The number of 5-HT+C was measured respectively before and two weeks after treatment by immunohistochemical method. RESULTS: The number of 5-HT+C decreased after treatment in all the three groups (P<0.05), but the decrement was more significant in the two test groups than in the control group (P<0.05 and P<0.01, respectively), while comparison of 5-HT+C between the two test groups showed insignificant difference (P>0.05). CONCLUSION: SJG can reduce the number of 5-HT+C in IBS patients of SGAP syndrome type, and its effect is enhanced when used in combination with Smecta.
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Authors | Zai-jian Wang, Hui-xia Li, Jing-hua Wang, Fan Zhang |
Journal | Chinese journal of integrative medicine
(Chin J Integr Med)
Vol. 14
Issue 3
Pg. 185-9
(Sep 2008)
ISSN: 1672-0415 [Print] China |
PMID | 18853113
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Drugs, Chinese Herbal
- shugan jianpi
- Serotonin
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Topics |
- Adult
- Cell Count
- Drugs, Chinese Herbal
(pharmacology, therapeutic use)
- Female
- Humans
- Immunohistochemistry
- Intestinal Mucosa
(drug effects, pathology)
- Irritable Bowel Syndrome
(drug therapy, pathology)
- Male
- Medicine, Chinese Traditional
- Middle Aged
- Phytotherapy
- Serotonin
(metabolism)
- Syndrome
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