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Patients with oral erosive and cutaneous lichen planus may have antibodies directed against the chronic ulcerative stomatitis protein antigen of 70-kDa.

AbstractOBJECTIVE:
The aim of this study is to verify whether stratified epithelium-specific antinuclear antibodies are present in the sera of patients with erosive oral lichen planus and cutaneous lichen planus.
METHODS:
We studied the pre-immune and immune serum of a rabbit immunized with a peptide corresponding to the N-terminus of the 70-kDa antigen chronic ulcerative stomatitis protein; sera from two patients, one with oral erosive lichen planus and one with cutaneous lichen planus who presented stratified epithelium-specific antinuclear antibodies at high titer; and a third serum from a patient with cutaneous lichen planus without stratified epithelium-specific antinuclear antibodies.
RESULTS:
We demonstrated that the protein bands recognized by the serum of the rabbit immunized with an epitope of chronic ulcerative stomatitis protein co-migrated by SDS-PAGE with the protein bands recognized by the serum of a patient affected by oral erosive lichen planus and by the serum of a patient with cutaneous lichen planus, both containing antibodies directed against a 70-kDa antigen.
CONCLUSIONS:
Our results confirm that antibodies specifically directed against the chronic ulcerative stomatitis protein are not a distinctive marker of chronic ulcerative stomatitis, but may also be detected in oral erosive and cutaneous lichen planus.
AuthorsEmanuele Cozzani, Marco Cacciapuoti, Eddi di Marco, Barbara Zerega, Fiorella Descalzi Cancedda, Aurora Parodi
JournalActa dermatovenerologica Alpina, Pannonica, et Adriatica (Acta Dermatovenerol Alp Pannonica Adriat) Vol. 17 Issue 3 Pg. 120-4 (Sep 2008) ISSN: 1318-4458 [Print] Slovenia
PMID18853074 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antibodies, Antinuclear
  • Nuclear Proteins
Topics
  • Antibodies, Antinuclear (blood)
  • Case-Control Studies
  • Electrophoresis, Polyacrylamide Gel
  • Epithelium (immunology, pathology)
  • Female
  • Gingivitis, Necrotizing Ulcerative (blood, immunology)
  • Humans
  • Lichen Planus, Oral (blood, pathology)
  • Male
  • Middle Aged
  • Nuclear Proteins (immunology)

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