Efficacy of ciprofloxacin and moxifloxacin against Nocardia brasiliensis in vitro and in an experimental model of actinomycetoma in BALB/c mice.

Abstract

The efficacy of ciprofloxacin and moxifloxacin against Nocardia brasiliensis was evaluated by applying 25 mg of each drug/kg subcutaneously every 8 h in BALB/c mice infected with N. brasiliensis. A statistically significant difference was observed only with moxifloxacin. A moxifloxacin-trimethoprim-sulfamethoxazole combination was as active as when each compound was used alone.

• Authors: Brenda Edith Chacon-Moreno, Oliverio Welsh, Norma Cavazos-Rocha, Maria de la Luz Salazar-Cavazos, Hector Gerardo Garza-Lozano, Salvador Said-Fernandez, Jorge Ocampo-Candiani, Lucio Vera-Cabrera
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 53 Issue 1 Pg. 295-7 (Jan 2009) ISSN: 1098-6596 [Electronic] United States
• PMID: 18852277 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Aza Compounds
• Fluoroquinolones
• Quinolines
• Ciprofloxacin
• Moxifloxacin

Topics

• Animals
• Aza Compounds (pharmacology)
• Ciprofloxacin (pharmacology)
• Disease Models, Animal
• Female
• Fluoroquinolones
• Mice
• Mice, Inbred BALB C
• Microbial Sensitivity Tests
• Moxifloxacin
• Mycetoma (drug therapy, microbiology)
• Nocardia (drug effects, pathogenicity)
• Quinolines (pharmacology)