Abstract | BACKGROUND/AIMS: METHODS: This prospective study included 140 cases of AP. Mild (n = 124) and severe (n = 16) cases were compared with respect to serum levels of trypsinogen-2, proCAP, amylase, aCAP, CAPAP (serum/urine), MCP-1 (serum/urine) and CRP on days 1, 2 and 3 from onset of symptoms. All patients with information on all 3 days were included in a time-course analysis (n = 44-55, except amylase: n = 27). RESULTS: High levels in severe versus mild cases were seen for trypsinogen-2, CAPAP in serum and urine, and MCP-1 in serum on days 1-3. No differences were seen for proCAP, amylase and aCAP. MCP-1 in urine was significantly elevated on day 1-2, and CRP on day 2-3. CAPAP and MCP-1 levels peaked early and stayed elevated for 48 h in serum. CONCLUSION:
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Authors | S Regnér, J Manjer, S Appelros, C Hjalmarsson, J Sadic, A Borgström |
Journal | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
(Pancreatology)
Vol. 8
Issue 6
Pg. 600-7
( 2008)
ISSN: 1424-3911 [Electronic] Switzerland |
PMID | 18849642
(Publication Type: Journal Article)
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Copyright | Copyright 2008 S. Karger AG, Basel and IAP. |
Chemical References |
- CCL2 protein, human
- Chemokine CCL2
- PRSS2 protein, human
- Trypsinogen
- C-Reactive Protein
- Amylases
- Peptide Hydrolases
- Carboxypeptidase B
- Trypsin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Amylases
(blood)
- C-Reactive Protein
(metabolism)
- Carboxypeptidase B
(blood)
- Chemokine CCL2
(blood, urine)
- Enzyme Activation
- Female
- Humans
- Inflammation
- Male
- Middle Aged
- Pancreatitis
(classification, enzymology, physiopathology)
- Peptide Hydrolases
(blood)
- Trypsin
(blood)
- Trypsinogen
(blood)
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