[Effects of Shengqing Capsule on biochemical parameters in mice with cholesterol gallstone].

Abstract

OBJECTIVE:

To observe the effects of Shengqing Capsule (SQC), a compound of traditional Chinese herbal medicine, on biochemical parameters in C57BL/6J mice with cholesterol gallstone.

METHODS:

Thirty-eight C57BL/6J mice were randomly divided into normal control group (n=10), untreated group (n=15) and SQC group (n=13). Cholesterol gallstone was induced in mice of the latter two groups by feeding high cholesterol diet. Mice in the SQC group were intragastricly administered SQC 0.22 g/(kg.d). After 8-week treatment, animals were sacrificed and sampled to calculate the incidences of stone formation. The contents of serum cholesterols and Ca(2+), and the malonaldehyde (MDA) content and superoxide dismutase (SOD) activity in liver tissues were detected.

RESULTS:

The incidences of stone formation were 73.33% in untreated group, 0% in normal control group, and 23.08% in the SQC group. And the INCIDENCE in untreated group was significantly higher than those in the normal control group and the SQC group (P<0.01). Contents of serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in the SQC group were lower than that in the untreated group (P<0.01), and high-density lipoprotein cholesterol (HDL-C) in the SQC group was higher than that in the untreated group (P<0.01). SQC could increase the SOD activity and decrease the MDA content in liver tissues, showing significant differences as compared with those in the untreated group (P<0.05).

CONCLUSION:

SQC can decrease the incidence of stone formation and improve the biochemical parameters, which may be one of the mechanisms in the treatment and prevention of cholesterol gallstone disease.

• Authors: Xue-Lin Zhang, Xiao-Qiang Liang, Hong-Gang Gu, En-Wei Ma, Tian-Bi Lin, Xun Sun, Jing-Zhe Zhang
• Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine (Zhong Xi Yi Jie He Xue Bao) Vol. 6 Issue 10 Pg. 1045-8 (Oct 2008) ISSN: 1672-1977 [Print] China
• PMID: 18847540 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Capsules
• Drugs, Chinese Herbal
• Lipoproteins
• shengqing
• Cholesterol
• Superoxide Dismutase

Topics

• Animals
• Capsules
• Cholesterol (blood)
• Drugs, Chinese Herbal (pharmacology, therapeutic use)
• Female
• Gallstones (chemistry, metabolism, prevention & control)
• Lipoproteins (blood)
• Mice
• Mice, Inbred C57BL
• Phytotherapy
• Random Allocation
• Superoxide Dismutase (metabolism)