Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-alpha treatment in a suspected case of hyper-IgE syndrome.

Abstract

We are reporting on a 7-months-old boy with suspected hyper-IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon-alpha (IFN-alpha) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T-cell cytokine production, indicating a valid therapeutic potential of IFN-alpha as immunomodulating drug.

• Authors: Ulrike Benninghoff, Federica Cattaneo, Alessandro Aiuti, Alberto Flores-D'Arcais, Carlo Gelmetti, Matteo Viscardi, Luciano Callegaro, Massimiliano Mirolo, Alessandro Ambrosi, Maria Grazia Roncarolo, Rosa Bacchetta
• Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (Pediatr Allergy Immunol) Vol. 19 Issue 6 Pg. 564-8 (Sep 2008) ISSN: 1399-3038 [Electronic] England
• PMID: 18844858 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cytokines
• Interferon alpha-2
• Interferon-alpha
• Recombinant Proteins
• Immunoglobulin E

Topics

• Child
• Cytokines (analysis, immunology)
• Eczema (drug therapy, immunology)
• Eosinophilia (immunology)
• Humans
• Immunoglobulin E (blood)
• Interferon alpha-2
• Interferon-alpha (therapeutic use)
• Job Syndrome (drug therapy, immunology)
• Male
• Recombinant Proteins
• Th1 Cells (immunology, metabolism)
• Th2 Cells (immunology, metabolism)