| Abstract | There is a worldwide epidemic of increasingly drug-resistant TB. Bacillus Calmette-Guérin vaccination provides partial protection against disseminated disease in infants but poor protection against later pulmonary TB. Cell-mediated protection against respiratory virus infections requires the presence of T cells in lung tissues, and the most effective prime-boost immunizations for Mycobacterium tuberculosis also induce lung-resident lymphocytes. These observations need to be taken into account when designing future vaccines against M. tuberculosis. |
| Authors | Peter Charles Leonard Beverley, Elma Zaven Tchilian
(Affiliation: The University of Oxford, Nuffield Department of Clinical Medicine, Edward Jenner Institute for Vaccine Research, Compton, Berkshire, RG20 7NN, UK. peter.beverley at jenner.ac.uk)
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| Journal | Expert review of vaccines
(Expert Rev Vaccines)
Vol. 7
Issue 8
Pg. 1165-72
(Oct 2008)
ISSN: 1744-8395 England |
| PMID | 18844591
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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| Chemical References |
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| Topics |
- Humans
- Lung
(immunology)
- Mycobacterium bovis
(immunology)
- Respiratory Tract Infections
(immunology)
- T-Lymphocytes
(immunology)
- Tuberculosis Vaccines
(immunology)
- Virus Diseases
(immunology)
|
