Effectiveness of vaginal administration of Lactobacillus rhamnosus following conventional metronidazole therapy: how to lower the rate of bacterial vaginosis recurrences.

Abstract

Eighty-four patients with bacterial vaginosis diagnosed according to Amsel's criteria were randomized to receive either oral metronidazole 500 mg twice a day for seven days, or one vaginal tablet containing freeze-dried Lactobacillus rhamnosus once a week at bedtime for two months starting one week after the last antibiotic administration. Followup was performed at days 30, 90 and 180. Chi-squared analysis showed a significant difference between the two treatment groups at day 90 (P = 0.05). Safe and effective long-term vaginal administration of Lactobacillus rhamnosus appears to be a useful complementary approach in the management of bacterial vaginosis.

• Authors: Valentina Marcone, Ettore Calzolari, Marco Bertini
• Journal: The new microbiologica (New Microbiol) Vol. 31 Issue 3 Pg. 429-33 (Jul 2008) ISSN: 1121-7138 [Print] Italy
• PMID: 18843900 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Bacterial Agents
• Metronidazole

Topics

• Administration, Intravaginal
• Administration, Oral
• Adult
• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• Complementary Therapies
• Female
• Humans
• Lacticaseibacillus rhamnosus
• Metronidazole (administration & dosage, therapeutic use)
• Probiotics (administration & dosage, therapeutic use)
• Secondary Prevention
• Vaginosis, Bacterial (drug therapy, prevention & control)