Sequential Ewing's sarcoma and osteosarcoma.

Abstract

The sequential occurrence of two primary bone tumors, Ewing's sarcoma and osteosarcoma in the same patient at two different anatomical sites 5 years apart is rare. We report a case of 12-year-old boy who after treatment for Ewing's sarcoma of proximal fibula subsequently presented, 4 years later, with a high-grade fibroblastic osteosarcoma of the proximal humerus. The patient was also found to have a rare gene tranlocation t (7;22) instead of the more common t (11;22).

• Authors: Vivek Sharma, Alvin H Crawford, Jonathan Evans, Margaret H Collins
• Journal: Journal of pediatric orthopedics. Part B (J Pediatr Orthop B) Vol. 17 Issue 6 Pg. 333-7 (Nov 2008) ISSN: 1473-5865 [Electronic] United States
• PMID: 18841070 (Publication Type: Case Reports, Journal Article)

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bone Neoplasms (genetics, pathology, therapy)
• Child
• Chromosomes, Human, Pair 22
• Chromosomes, Human, Pair 7
• Combined Modality Therapy
• Fibula (pathology)
• Humans
• Humerus (pathology)
• Male
• Neoplasms, Second Primary (genetics, pathology)
• Osteosarcoma (genetics, pathology)
• Radiotherapy, Adjuvant
• Sarcoma, Ewing (genetics, pathology, therapy)
• Translocation, Genetic