Abstract | BACKGROUND: DESIGN: RESULTS: Compared with weight maintenance (n = 15), weight loss (n = 20) significantly decreased body weight, plasma insulin, triglycerides, total cholesterol, low-density lipoprotein ( LDL)-cholesterol and lathosterol (P < 0.05). Weight loss also decreased plasma concentrations of apoC-III (-33%), apoB-48 (-37%), very low-density lipoprotein (VLDL)- apoB (-43%), RLP- cholesterol (-48%), and RBP-4 (-20%), and significantly increased plasma total (+20%) and HMW- adiponectin (+19%) concentrations. In the weight loss group, reduction in plasma apoC-III was associated (P < 0.05) with reduction in plasma apoB-48, VLDL- apoB, RLP- cholesterol and triglycerides. Increase in total adiponectin was associated (P < 0.05) with the reduction in plasma VLDL- apoB and triglycerides. The changes in HMW- adiponectin and RBP-4 were not associated with changes in plasma apoB-48, apoC-III, VLDL- apoB, RLP- cholesterol or triglycerides. In multiple regression analysis including changes in visceral fat, insulin and total adiponectin concentrations, the fall in plasma apoC-III concentration was an independent predictor of the reductions in plasma apoB-48, VLDL- apoB, RLP- cholesterol and triglycerides concentrations. CONCLUSIONS:
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Authors | D C Chan, G F Watts, T W K Ng, S Yamashita, P H R Barrett |
Journal | European journal of clinical investigation
(Eur J Clin Invest)
Vol. 38
Issue 10
Pg. 743-51
(Oct 2008)
ISSN: 1365-2362 [Electronic] England |
PMID | 18837799
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Apolipoprotein B-48
- Apolipoprotein C-III
- Apolipoproteins B
- Biomarkers
- Cytokines
- Lipoproteins
- Triglycerides
- Cholesterol
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Topics |
- Adult
- Apolipoprotein B-48
(analysis)
- Apolipoprotein C-III
(analysis)
- Apolipoproteins B
(analysis)
- Biomarkers
(analysis)
- Cholesterol
(analysis)
- Cytokines
(analysis)
- Enzyme-Linked Immunosorbent Assay
- Humans
- Linear Models
- Lipoproteins
(metabolism)
- Male
- Metabolic Syndrome
(diet therapy, metabolism)
- Middle Aged
- Triglycerides
(metabolism)
- Weight Loss
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