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Type I (sporadic) porphyria cutanea tarda in a hemodialysis patient: a case report.

Abstract
A hemodialysis patient with hepatitis C virus infection developed painful blisters on her hands that burst spontaneously. She was found to have serum porphyrin levels >2000 nmol/L. A punch biopsy revealed subepidermal blistering with festooning of dermal papillae associated with a mixed inflammatory infiltrate. Based on the clinical, biochemical, and histologic findings, a diagnosis of porphyria cutanea tarda was made. Treatment was started with twice-weekly phlebotomy and oral hydroxychloroquine and significant clinical improvement resulted.
AuthorsKurt Tarwater, Shamita Misra, Madhukar Misra
JournalHemodialysis international. International Symposium on Home Hemodialysis (Hemodial Int) Vol. 12 Suppl 2 Pg. S38-42 (Oct 2008) ISSN: 1492-7535 [Print] Canada
PMID18837769 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Enzyme Inhibitors
  • Hydroxychloroquine
Topics
  • Enzyme Inhibitors (administration & dosage)
  • Female
  • Hepatitis C (complications)
  • Humans
  • Hydroxychloroquine (administration & dosage)
  • Kidney Failure, Chronic (complications, therapy)
  • Middle Aged
  • Phlebotomy
  • Porphyria Cutanea Tarda (complications, drug therapy)
  • Renal Dialysis

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