Feline thyroid carcinoma: diagnosis and response to high-dose radioactive iodine treatment.

Abstract

This study reports the scintigraphy, histopathology, sole treatment with high-dose radioactive iodine and outcome of eight cases of feline thyroid carcinoma. Scintigraphic findings were variable and in 7/8 cases scintigraphic features could not reliably distinguish whether the thyroid tissue was malignant. Histopathology revealed typical criteria of malignancy in all cases, with mitotic activity described most frequently (7/8 cases), followed by infiltration of local tissues (4/8 cases). Cellular pleomorphism was infrequently observed. Single high-dose (1100MBq I(131)) radioiodine therapy was successful in 6/8 cases, with complete resolution of hyperthyroidism, and was associated with prolonged survival times (181-2381 days). Sole treatment with high-dose radioiodine is a safe and effective treatment for functional thyroid carcinoma. The prognosis for feline thyroid carcinoma successfully treated with radioiodine is good, with extended survival times commonly achieved.

• Authors: Angie Hibbert, Tim Gruffydd-Jones, Esther L Barrett, Michael J Day, Andrea M Harvey
• Journal: Journal of feline medicine and surgery (J Feline Med Surg) Vol. 11 Issue 2 Pg. 116-24 (Feb 2009) ISSN: 1098-612X [Print] England
• PMID: 18835538 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Iodine Radioisotopes

Topics

• Animals
• Cat Diseases (diagnosis, etiology, radiotherapy)
• Cats
• Female
• Hyperthyroidism (etiology, veterinary)
• Iodine Radioisotopes (administration & dosage)
• Lung Neoplasms (secondary, veterinary)
• Male
• Radionuclide Imaging (veterinary)
• Surveys and Questionnaires
• Survival Analysis
• Thyroid Gland (diagnostic imaging, pathology)
• Thyroid Neoplasms (diagnosis, radiotherapy, veterinary)
• Treatment Outcome
• United Kingdom