International Nosocomial Infection Control Consortium report, data summary for 2002-2007, issued January 2008.

Abstract

We report the results of an International Nosocomial Infection Control Consortium (INICC) surveillance study from 2002 through 2007 in 98 intensive care units (ICUs) in Latin America, Asia, Africa, and Europe. During the 6-year study, using Centers for Disease Control and Prevention (CDC) National Nosocomial Infections Surveillance System (NNIS) definitions for device-associated health care-associated infection, we collected prospective data from 43,114 patients hospitalized in the Consortium's hospital ICUs for an aggregate of 272,279 days. Although device utilization in the INICC ICUs was remarkably similar to that reported from US ICUs in the CDC's National Healthcare Safety Network, rates of device-associated nosocomial infection were markedly higher in the ICUs of the INICC hospitals: the pooled rate of central line-associated bloodstream infections (CLABs) in the INICC ICUs, 9.2 per 1000 CL-days, is nearly 3-fold higher than the 2.4-5.3 per 1000 CL-days reported from comparable US ICUs, and the overall rate of ventilator-associated pneumonia was also far higher, 19.5 vs 1.1-3.6 per 1000 ventilator-days, as was the rate of catheter-associated urinary tract infection, 6.5 versus 3.4-5.2 per 1000 catheter-days. Most strikingly, the frequencies of resistance of Staphylococcus aureus isolates to methicillin (MRSA) (80.8% vs 48.1%), Enterobacter species to ceftriaxone (50.8% vs 17.8%), and Pseudomonas aeruginosa to fluoroquinolones (52.4% vs 29.1%) were also far higher in the Consortium's ICUs, and the crude unadjusted excess mortalities of device-related infections ranged from 14.3% (CLABs) to 27.5% (ventilator-associated pneumonia).

• Authors: Victor D Rosenthal, Dennis G Maki, Ajita Mehta, Carlos Alvarez-Moreno, Hakan Leblebicioglu, Francisco Higuera, Luis E Cuellar, Naoufel Madani, Zan Mitrev, Lourdes Dueñas, Josephine Anne Navoa-Ng, Humberto Guanche Garcell, Lul Raka, Rosalía Fernández Hidalgo, Eduardo A Medeiros, Souha S Kanj, Salisu Abubakar, Patricio Nercelles, Ricardo Diez Pratesi, International Nosocomial Infection Control Consortium Members
• Journal: American journal of infection control (Am J Infect Control) Vol. 36 Issue 9 Pg. 627-37 (Nov 2008) ISSN: 1527-3296 [Electronic] United States
• PMID: 18834725 (Publication Type: Journal Article)

Topics

• Africa (epidemiology)
• Asia (epidemiology)
• Cross Infection (epidemiology, microbiology, mortality)
• Drug Resistance, Bacterial
• Europe (epidemiology)
• Gram-Negative Bacterial Infections (microbiology, mortality)
• Gram-Positive Bacterial Infections (microbiology, mortality)
• Humans
• Intensive Care Units
• International Cooperation
• Latin America (epidemiology)
• Organizations
• Prevalence